Does BRAF V600E Mutation Enable Vemurafenib to be a Universal Candidate for Treating a Plethora of Cancers?
نویسنده
چکیده
Neurologically, BRAF V600E mutation was detected in cerebellar anaplastic pilocytic astrocytoma [6], ganglioglioma [7], desmoplastic infantile astrocytoma [8], indeterminate cell tumor and interdigitating dendritic cell sarcoma [9]. Hematologically, BRAF V600E mutation was also detected in multiple myeloma [10] and several leukemias (hairy cell, chronic lymphocytic, prolymphocytic and acute lymphoblastic leukaemia) [11-13].
منابع مشابه
BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers.
Oncogenic BRAF, which drives cell transformation and proliferation, has been detected in approximately 50% of human malignant melanomas and 5% to 15% of colorectal cancers. Despite the remarkable clinical activities achieved by vemurafenib and dabrafenib in treating BRAF(V600E) metastatic melanoma, their clinical efficacy in BRAF(V600E) colorectal cancer is far less impressive. Prior studies su...
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